The immunosuppressive effect of FK 506 on canine lung transplantation

Canine total orthotopic small bowel transplantation under FK 506.

Adult mongrel dogs of both sexes. weighing 12.5 to 29.0 kg. were used. Under anesthesia with isoflurane. the entire small bowel except the duodenum and 5 cm of the terminal ileum was isolated with its vascular pedicle. and excised. The graft was perfused on the back table with cold lactated Ringer's solution containing 2500 u/L of heparin. The transplantation technique was essentially the same ...

Kidney transplantation under FK 506.

The experimental immunosuppressive drug FK 506 was given to 36 renal transplant recipients, many of whom were highly sensitized. Ten were undergoing kidney retransplantation, 10 also underwent liver transplantation at an earlier time (6 patients) or concomitantly (4 patients), and 2 patients received a third organ (heart or pancreas) in addition to a liver and kidney. With follow-ups of 4 to 13...

FK-506, a novel immunosuppressant isolated from a Streptomyces. II. Immunosuppressive effect of FK-506 in vitro.

The immuno-pharmacological profile of a novel immunosuppressive agent, FK-506 produced by a streptomycete, is presented here. We proceeded to test the effect of the agent on various in vitro immune systems. It showed that mixed lymphocyte reaction, cytotoxic T cell generation, the production of T cell-derived soluble mediators such as interleukin 2 (IL-2), interleukin 3 and gamma-interferon and...

A cost comparison of liver transplantation with FK 506 or CyA as the primary immunosuppressive agent.

Preliminary Communication Kidney Transplantation Under FK 506

The experimental immunosuppressive drug FK 506 was given to 36 renal transplant recipients, many of whom were highly sensitized. Ten were undergoing kidney retransplantation, 10 also underwent liver transplantation at an earlier time (6 patients) or concomitantly (4 patients), and 2 patients received a third organ (heart or pancreas) in addition to a liver and kidney. With follow-ups of 4 to 13...